Endocrine Abstracts

Objective: To assess glucose metabolism (GM) parameters before and after vitamin D treatment in pre-diabetic women.Material and Methods: In the study were included fifty eight women with prediabetes (impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)) aged from 40 to 55 with signed informed consent. The study didn’t include women with diseases affecting the vitamin D metabolism, as well as women receiving regular vitamin D supplemen...

Hypothesis: High doses of vitamin D (VitD) improves dermal microcirculation (MC) in diabetic patients with type 2 diabetes mellitus (T2DM) and diabetic neuropathy (DN).Purpose: To study the effect of different VD doses on skin MC values in T2DM patients and DN.Materials and methods: Sixty-two non-smoking T2DM patients with DN were randomized into two groups: Group 1 received 5000 IU (G1) and Group 2 received 40000 IU (G2) of cholec...

Objective(s): Last data showed advantages of TBS assessment of bone quality over BMD in patients with type 2 diabetes (T2D). We perform DXA in patients with T2D and calculated 10-year probability of fracture using FRAX® tool.Material and methods: A total of 252 (172 females) T2D patients aged 36 to 86 y.o (mean 61.0±8.8) were examined. BMD was performed in 124 patients (110 females) using DXA (Lunar Prodigy, USA). BMD adjusted for TB...

Backgraund: Insulinoma is the most common functional pancreatic neuroendocrine tumor originating from β-cells, with unregulated insulin production and rarely associated with MEN-I syndrome. Diagnosis and treatment of insulinoma are a challenge in the practice of endocrinologist.Aim: To determine on the basis of retrospective analysis the optimal approaches to the management of patients with organic hyperinsulinism.Materials an...

Background: In recent years, the role of vitamin D in improving the profile of inflammatory markers in order to prevent and treat diabetic neuropathy and microcirculation disorders has been actively studied.Aims: The research goal was to study the dynamics of inflammatory markers, clinical manifestations of diabetic peripheral neuropathy and laser Doppler flowmetry of skin microcirculation during treatment with various doses of cholecalciferol in patient...

Purpose: Primary hyperparathyroidism (PHPT) is the third common endocrine disorder which often manifest with skeletal or renal disfunction. In developed countries asymptomatic form is the most common and such severe manifestations as osteofibrosis cystica are very rare.Clinical case: We present the case of 49-years-75 × 66 old caucasian woman, with history of urolithiasis, nephrolithotripsy in 2014. In November 2016 she was diagnosed with left femur...

Objective: Recent studies suggest that vitamin D deficiency could be a risk factor for metabolic abnormalities.The aim of this study was to assess the relationship between 25(OH)D level and metabolic syndrome components.Materials and methods: A total of 697 women from 30 to 55 y.o. were examined. Exclusion criteria were, clinically significant endocrine, renal, liver and GI diseases, regular insolation and intake of vitamin D and c...

Background and aims: The most outstanding cardioprotective potential has been demonstrated for GLP-1 receptor agonists (GLP-1RA) and SGLT-2 inhibitors (SGLT-2i). But only long-acting GLP-1RA dulaglutide (DULA) and semaglutide decrease stroke incidence, while data concerning the influence of any drug on stroke severity are lack. At the same time, ischemic stroke remains one of the leading causes of death in type 2 diabetes mellitus (DM2). The aim of our study was to investigate...

Background Fibrocystic osteitis is rare PHPT manifestation. Poor management and delay in diagnosis of fibrocystic osteitis may lead to reduced quality of life and also provoke severe postoperative hypocalcemia – «hungry bone» syndrome.Clinical case We present a case of 66-years-old Caucasian woman, with history of urulithiasis/nephrocalcinosis (CKD stage 4), two pathological fractures, and fibrocystic osteitis. In Jan 2021...

Background: Management of primary hyperparathyroidism (PHPT) in Multiple Endocrine Neoplasia type 1 syndrome (MEN 1) is still a challenge. PHPT developing in MEN 1 is characterized by the involvement of all parathyroid glands. Therefore, by modern guidelines, total or subtotal removal of the parathyroid glands is recommended. But this approach often leads to the development of hypoparathyroidism, adequate correction of which is not always possible. Drug therapy of recurrent PH...